Water → HCID 86651110, compound

HRID 1810321Notes

Reaction equation

HRID 1810321 reaction equation
[CH3:1][O:2][C:3](=[O:30])[C@@H:4]([C:6]1[CH:7]=[C:8]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:17]=2[CH2:26][NH:27][CH2:28][CH3:29])[CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[CH3:5].C(N(CC)CC)C.[CH2:38]([N:45]=[C:46]=[O:47])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1.O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:30])[C@@H:4]([C:6]1[CH:7]=[C:8]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:23])([F:24])[F:25])=[CH:18][C:17]=2[CH2:26][N:27]([CH2:28][CH3:29])[C:46]([NH:45][CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[O:47])[CH:9]=[C:10]([C:12]([F:14])([F:15])[F:13])[CH:11]=1)[CH3:5]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 76639Benzyl isocyanateHCID 86651109HCID 86651109, compound

Product 1

HCID 86651110HCID 86651110, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

(R)-2-(2′-Ethylaminomethyl-5,4′-bis-trifluoromethyl-biphenyl-3-yl)-propionic acid methyl ester (0.10 mmol) in CH2Cl2 was treated with triethylamine (0.03 mL, 0.20 mmol) and benzyl isocyanate (0.02 mL, 0.20 mmol) at room temperature for 2 hours. The mixture was worked up with CH2Cl2 and H2O to give the title compound.

Sources & evidence

ORD record
ord-6b8b6fbea51a4dcf909c5826691b759f
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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