HCID 66606831, compound → HCID 66607287, compound

HRID 1810411Notes

Reaction equation

HRID 1810411 reaction equation
[CH2:1]([O:3][C:4](=[O:39])[CH:5]([C:7]1[CH:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=2[CH2:25][N:26](C(OCC2C=CC=CC=2)=O)[CH2:27][CH3:28])[C:10]([O:13][CH3:14])=[CH:11][CH:12]=1)[CH3:6])[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:39])[CH:5]([C:7]1[CH:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=2[CH2:25][NH:26][CH2:27][CH3:28])[C:10]([O:13][CH3:14])=[CH:11][CH:12]=1)[CH3:6])[CH3:2]

Participants

4

Reactant 1

HCID 66606831HCID 66606831, compound

Product 1

HCID 66607287HCID 66607287, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 2-{2′-[(benzyloxycarbonyl-ethyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-propionic acid ethyl ester (0.11 mmol) in EtOH (12 mL) was added 10% palladium on carbon (0.050 g), and the reaction was stirred under a balloon of H2 at room temperature for 1 hour. The mixture was filtered through a pad of Celite and rinsed with EtOH. The filtrate was concentrated to give the title compound.

Workup

  1. filtrationThe mixture was filtered through a pad of Celite
  2. washrinsed with EtOH
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-36fd1493b5d44dcdb809396b02f207dc
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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