Bromomethylcyclopropane → (3-Bromo-4-cyclopropylmethoxy-phenyl)-acetic acid ethyl ester

HRID 1810429Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([Br:13])[CH:7]=1)[CH3:2].Br[CH2:16][CH:17]1[CH2:19][CH2:18]1>>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:16][CH:17]2[CH2:19][CH2:18]2)=[C:8]([Br:13])[CH:7]=1)[CH3:2]

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 18620106Ethyl 2-(3-bromo-4-hydroxyphenyl)acetate

Product 1

HCID 58149222(3-Bromo-4-cyclopropylmethoxy-phenyl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 123, Step 1, using the following starting materials: (3-bromo-4-hydroxy-phenyl)-acetic acid ethyl ester and (bromomethyl)cyclopropane.

Workup

customPrepared

Sources & evidence

ORD record: ord-1f182385a34140fa8806d30da00251af
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08362044B2

Reaction notes

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