Ethanol → HCID 58149300, compound

HRID 1810442Notes

Reaction equation

HRID 1810442 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1.S(=O)(=O)(O)O.C(Cl)Cl.O.[CH3:22][CH2:23]O>>[CH2:22]([O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Br:1])[CH:3]=1)[CH3:23]

Participants

6

Reactant 5

HCID 702EthanolHCID 962WaterHCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 153652222-(3-Bromo-5-chlorophenyl)acetic acid

Product 1

HCID 58149300HCID 58149300, compound

Procedure

(3-Bromo-5-chloro-phenyl)-acetic acid (14 g, 56 mmol) in EtOH (150 mL) was treated with sulfuric acid (2 mL) at 50° C. for 2 hours. The mixture was worked-up with CH2Cl2 and H2O, and the organic layer was concentrated to give the title compound.

Workup

  1. concentrationthe organic layer was concentrated

Sources & evidence

ORD record
ord-3e8efc02cf1b4409a2e8eb525988b8d1
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

Loading…