Cyclopropanecarbonyl chloride → HCID 58149262, compound

HRID 1810482Notes

Reaction equation

HRID 1810482 reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:32])[CH2:6][C:7]1[CH:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][N:22]=3)=[CH:17][C:16]=2[CH2:28][NH:29][CH2:30][CH3:31])[C:10]([O:13][CH3:14])=[CH:11][CH:12]=1)[CH3:3].[CH:33]1([C:36](Cl)=[O:37])[CH2:35][CH2:34]1>>[CH2:2]([O:4][C:5](=[O:32])[CH2:6][C:7]1[CH:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][N:22]=3)=[CH:17][C:16]=2[CH2:28][N:29]([C:36]([CH:33]2[CH2:35][CH2:34]2)=[O:37])[CH2:30][CH3:31])[C:10]([O:13][CH3:14])=[CH:11][CH:12]=1)[CH3:3]

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 131730182HCID 131730182, compound

Product 1

HCID 58149262HCID 58149262, compound

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: [2′-ethylaminomethyl-4′-(5-fluoro-pyridin-2-yl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester, hydrochloride and cyclopropanecarbonyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1e782bc0fc7f4171a831eb348e46b2b6
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

Loading…