3,5-Difluorobenzyl Chloroformate → (2'-{[(3,5-Difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6'-methoxy-biphenyl-3-yl)-acetic acid methyl ester

HRID 1810489Notes

Reaction equation

HRID 1810489 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:19][NH:20][CH2:21][CH3:22])[CH:8]=[CH:9][CH:10]=1.Cl[C:25]([O:27][CH2:28][C:29]1[CH:34]=[C:33]([F:35])[CH:32]=[C:31]([F:36])[CH:30]=1)=[O:26]>>[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:19][N:20]([C:25]([O:27][CH2:28][C:29]2[CH:30]=[C:31]([F:36])[CH:32]=[C:33]([F:35])[CH:34]=2)=[O:26])[CH2:21][CH3:22])[CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 574588023,5-Difluorobenzyl ChloroformateHCID 58149181(2'-Ethylaminomethyl-6'-methoxy-biphenyl-3-yl)-acetic acid methyl ester

Product 1

HCID 58148900(2'-{[(3,5-Difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6'-methoxy-biphenyl-3-yl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-ethylaminomethyl-6′-methoxy-biphenyl-3-yl)-acetic acid methyl ester and 3,5-difluorobenzyl chloroformate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4512f0230d444904a97f583cab102410
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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