Hydrochloric Acid → Methyl 2-(5-bromo-2-methoxyphenyl)acetate

HRID 1810527Notes

Reaction equation

HRID 1810527 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1.Cl.[CH3:15]O>O1CCOCC1>[CH3:15][O:10][C:9](=[O:11])[CH2:8][C:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=1[O:12][CH3:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 5553065-Bromo-2-methoxyphenylacetic acid

Product 1

HCID 21999895Methyl 2-(5-bromo-2-methoxyphenyl)acetate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

5-Bromo-2-methoxyphenylacetic acid (0.900 g, 3.67 mmol) in MeOH (20 mL) was treated with 4N HCl in 1,4-dioxane (4 mL) and stirred at 80° C. for 6 hours. The mixture was concentrated to give the title compound.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-2f852c9f948548d4ae15a589aedc038e
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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