Acetic Acid → 2-(5-Bromo-2-fluorophenyl)acetic acid

HRID 1810545Notes

Reaction equation

HRID 1810545 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6](CC#N)[CH:7]=1.[C:12]([OH:15])(=[O:14])[CH3:13].S(=O)(=O)(O)O>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:11])=[C:4]([CH2:13][C:12]([OH:15])=[O:14])[CH:3]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 235096312-(5-Bromo-2-fluorophenyl)acetonitrile

Product 1

HCID 35846902-(5-Bromo-2-fluorophenyl)acetic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

(5-Bromo-2-fluoro-phenyl)-acetonitrile (0.5 g, 2.3 mmol) was treated with acetic acid (2 mL) and sulfuric acid (2 mL) in H2O (2 mL) at 95° C. for 5 hours. Aqueous worked-up afforded the title compound.

Sources & evidence

ORD record
ord-726ef524f4d445c29d58ec6b01609026
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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