Hydrochloric Acid → (5-Bromo-2-fluoro-phenyl)-acetic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Methanol	HCID 887	—
Reactant	2-(5-Bromo-2-fluorophenyl)acetic acid	HCID 3584690	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	(5-Bromo-2-fluoro-phenyl)-acetic acid methyl ester	HCID 58148958	—

Reaction Conditions

Temperature	90 °C

Reaction Steps

To a solution of (5-bromo-2-fluoro-phenyl)-acetic acid (2.3 mmol) in MeOH (15 mL) was added 4N HCl in 1,4-dioxane (2 mL), and the reaction was stirred at 90° C. for 2 hours. The mixture was concentrated, and the residue was purified by silica gel chromatography to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08362044B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-cf108a57adc44f218f91810d6e0ed841
Source note	uspto-grants-2013_01