Hydrochloric Acid → (5-Bromo-2-fluoro-phenyl)-acetic acid methyl ester

HRID 1810546Notes

Reaction equation

HRID 1810546 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:12])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1.Cl.[CH3:14]O>O1CCOCC1>[CH3:14][O:10][C:9](=[O:11])[CH2:8][C:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=1[F:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 35846902-(5-Bromo-2-fluorophenyl)acetic acid

Product 1

HCID 58148958(5-Bromo-2-fluoro-phenyl)-acetic acid methyl ester

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of (5-bromo-2-fluoro-phenyl)-acetic acid (2.3 mmol) in MeOH (15 mL) was added 4N HCl in 1,4-dioxane (2 mL), and the reaction was stirred at 90° C. for 2 hours. The mixture was concentrated, and the residue was purified by silica gel chromatography to give the title compound.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-cf108a57adc44f218f91810d6e0ed841
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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