HCID 66607775, compound → HCID 66607438, compound

HRID 1810556Notes

Reaction equation

HRID 1810556 reaction equation
C(OC([N:11]([CH2:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:16]=1[C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[C:27]([CH2:32][C:33]([OH:35])=[O:34])[CH:26]=1)[CH2:12][CH3:13])=O)C1C=CC=CC=1>[Pd].CO>[CH2:12]([NH:11][CH2:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:16]=1[C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[C:27]([CH2:32][C:33]([OH:35])=[O:34])[CH:26]=1)[CH3:13]

Participants

4

Reactant 1

HCID 66607775HCID 66607775, compound

Product 1

HCID 66607438HCID 66607438, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of {2′-[(benzyloxycarbonyl-ethyl-amino)-methyl]-5-fluoro-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid (0.025 g, 0.05 mmol) and 10% palladium on carbon (catalytic) in MeOH was hydrogenated under a balloon of H2 at room temperature for 2 hours. The mixture was filtered through a pad of Celite, and the filtrate was concentrated to give the title compound. M+H is 382.

Workup

  1. filtrationThe mixture was filtered through a pad of Celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-16e1decc59e44f9f97f38af5581098b5
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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