Lithium Hydroxide → HCID 66608277, compound

HRID 1810559Notes

Reaction equation

HRID 1810559 reaction equation
C[O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[CH:8]=[C:9]([Cl:11])[CH:10]=1.[Li+].[OH-]>O1CCOCC1>[Cl:11][C:9]1[CH:10]=[C:5]([CH2:4][C:3]([OH:26])=[O:2])[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[CH:8]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66606869HCID 66606869, compound

Product 1

HCID 66608277HCID 66608277, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(5-Chloro-2′-ethylaminomethyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester (0.010 g, 0.03 mmol) in 1,4-dioxane (2 mL) was treated with 1N aqueous LiOH (1 mL) at room temperature for 1 hour. The solution was neutralized to pH 6 and extracted with EtOAc, and the combined organic layers were concentrated and purified by preparative HPLC to give the title compound.

Workup

  1. extractionextracted with EtOAc
  2. concentrationthe combined organic layers were concentrated
  3. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-c03d85b353b84ba9a08bf3c43ae3f46c
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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