Oxalyl chloride → HCID 86651138, compound

HRID 1810586Notes

Reaction equation

[CH:1]1([C:4]([N:6]([CH2:9][C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:11]=2[C:20]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([CH:30]([CH3:34])[C:31](O)=[O:32])[CH:21]=2)[CH2:7][CH3:8])=[O:5])[CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:38])=O>>[CH:1]1([C:4]([N:6]([CH2:9][C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:11]=2[C:20]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([CH:30]([CH3:34])[C:31]([Cl:38])=[O:32])[CH:21]=2)[CH2:7][CH3:8])=[O:5])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 65578Oxalyl chloride

HCID 86651139HCID 86651139, compound

Product 1

HCID 86651138HCID 86651138, compound

Procedure

Prepared according to the procedure described in Example 218, Step 3, using the following starting materials: 2-{2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-5,4′-bis-trifluoromethyl-biphenyl-3-yl}-propionic acid and oxalyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-5b6a375712b34f2c963f16351d2ca5d2
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08362044B2

Reaction notes

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