反应详情

The above ester (0.36 g, 0.658 mmol) was dissolved in ethanol (30 mL), a solution of lithium hydroxide monohydrate (0.10 g, 2.38 mmol) in water (4 mL) was added and the mixture was left to stand for 72 h. The solvents were evaporated in vacuo; the residue was diluted with water (25 mL), acidified with acetic acid (0.25 mL) and extracted with chloroform (2×50 mL). The organic solution was dried with anhydrous potassium carbonate and subsequently evaporated in vacuo. The residue was triturated with hexanes (2×20 mL) yielding the title compound as amorphous solid.

1. waitthe mixture was left
2. customThe solvents were evaporated in vacuo
3. additionthe residue was diluted with water (25 mL)
4. extractionextracted with chloroform (2×50 mL)
5. dry with materialThe organic solution was dried with anhydrous potassium carbonate
6. customsubsequently evaporated in vacuo
7. customThe residue was triturated with hexanes (2×20 mL)