反应详情

The compound of example 16 (35 mg, 0.078 mmol) was dissolved in acetic acid (2.5 ml), hydrogen peroxide (43 mg of a 30% solution in water, 0.38 mmol) was added and the mixture was stirred at room temperature for 2 h. The mixture was partitioned between EA and a 1% aqueous sodium sulfite solution, the aqueous phase extracted with EA, and the combined organic extracts were dried over sodium sulfate, filtered and evaporated to dryness to give 36 mg of the title compound.

1. customThe mixture was partitioned between EA
2. extractiona 1% aqueous sodium sulfite solution, the aqueous phase extracted with EA
3. dry with materialthe combined organic extracts were dried over sodium sulfate
4. filtrationfiltered
5. customevaporated to dryness