反应详情

温度

70 °C

N-(4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl)-L-glutamic acid diethyl ester p-toluenesulfonic acid salt (1.0 g) is dissolved in 6.7 mL aqueous sodium hydroxide and stirred until complete solution is obtained. 6 mL of water is added and the pH is adjusted to 3.0-3.5 by the addition of diluted hydrochloride acid. The resulting slurry is heated at 70° C. for an hour and then filtered to yield the title compound in 99.6% purity (HPLC).

1. customis obtained
2. filtrationfiltered