反应详情

A round bottom flask is charged with 5% platinum sulfide on carbon (0.200 g, 0.039 mmol). The flask is evacuated and refilled with argon three times. To the flask is added 1-[4-(5-chloro-3-nitro-pyridin-2-yl)-piperazin-1-yl]-2-(3,5-dimethyl-pyrazol-1-yl)-ethanone (1.10 g, 2.90 mmol) as a solution in a 1:1 mixture of ethyl acetate:methanol (100 mL). The mixture is placed under an atmosphere of hydrogen and stirred for 5 h at room temperature. The mixture is filtered through a pad of diatomaceous earth and concentrated under reduced pressure to provide 0.67 g of 1-[4-(3-amino-5-chloro-pyridin-2-yl)-piperazin-1-yl]-2-(3,5-dimethyl-pyrazol-1-yl)-ethanone as a white solid in 66% yield.

1. customThe flask is evacuated
2. additionrefilled with argon three times
3. filtrationThe mixture is filtered through a pad of diatomaceous earth
4. concentrationconcentrated under reduced pressure