HCID 57516332, compound → 1247075-58-6

HRID 1810987Notes

Reaction equation

HRID 1810987 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:5]=1)([O-])=O>CCO.[Pd]>[F:15][C:12]([F:13])([F:14])[CH2:11][O:10][C:6]1[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][N:7]=1

Participants

4

Reactant 1

HCID 57516332HCID 57516332, compound

Product 1

HCID 575163311247075-58-6Yield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-Nitro-2-(2,2,2-trifluoro-ethoxy)-pyridine (1.11 g, 5 mmol) in 40 mL EtOH and 50 mg 10% Pd/C is placed under hydrogen atmosphere at room temp for 16 h. The solvent is removed under reduced pressure to give 0.9 g, 100% yield of 2-(2,2,2-trifluoro-ethoxy)-pyridin-4-ylamine.

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-9ea68daaa8b24573a0ed4a1d85d44ed6
Source dataset
uspto-grants-2013_01
Patent number
US08362249B2

Reaction notes

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