反应详情

温度

120 °C

A mixture of 3-bromo-2-methylaniline (372 mg, 2.00 mmol), 1,2-bis(chloromethyl)benzene (385 mg, 2.20 mmol), and potassium carbonate (304 mg, 2.20 mmol) in water (2 mL) was heated via microwave irradiation in a sealed tube at 120° C. for 25 min. The mixture was extracted with EtOAc and the organic phase was washed with water, dried and concentrated. The residue was purified by column chromatography (eluting with a gradient from hexane to 30:70 EtOAc-hexane) to provide 2-(3-bromo-2-methylphenyl)isoindoline as a light yellow oil (360 mg, 63%). Mass spectrum m/z 288, 290 (M+H)+.

1. extractionThe mixture was extracted with EtOAc
2. washthe organic phase was washed with water
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by column chromatography (
6. washeluting with a gradient from hexane to 30:70 EtOAc-hexane)