反应详情

5-Benzyl-6-oxo-5,6-dihydrophenanthridine-2-carbonitrile (1.24 g) and Raney nickel (0.8 g) were suspended in 75% formic acid (25 ml). The suspension was heated under reflux for 1 hour and 40 minutes, and filtered while hot. The filtrate was concentrated and purified by silica gel chromatography (methylene chloride:methanol=50:1) to thereby obtain 1.08 g (yield: 80%) of the title compound as a colorless crystals.

1. temperatureThe suspension was heated
2. temperatureunder reflux for 1 hour and 40 minutes
3. filtrationfiltered while hot
4. concentrationThe filtrate was concentrated
5. custompurified by silica gel chromatography (methylene chloride:methanol=50:1)