Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formic Acid → 5-Benzyl-6-oxo-5,6-dihydrophenanthridine-2-carboxaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formic Acid | HCID 284 | — |
| 반응물 | 5-Benzyl-6-oxo-5,6-dihydrophenanthridine-2-carbonitrile | HCID 66596809 | — |
| 촉매 | Nickel | HCID 935 | — |
| 생성물 | 5-Benzyl-6-oxo-5,6-dihydrophenanthridine-2-carboxaldehyde | HCID 86233783 | 80% |
반응 단계
5-Benzyl-6-oxo-5,6-dihydrophenanthridine-2-carbonitrile (1.24 g) and Raney nickel (0.8 g) were suspended in 75% formic acid (25 ml). The suspension was heated under reflux for 1 hour and 40 minutes, and filtered while hot. The filtrate was concentrated and purified by silica gel chromatography (methylene chloride:methanol=50:1) to thereby obtain 1.08 g (yield: 80%) of the title compound as a colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08362252B2 |
| 출처 데이터셋 | uspto-grants-2013_01 |
| ORD ID | ord-320d901322fc43459cff173567946ca8 |
| 출처 메모 | uspto-grants-2013_01 |