2-Methoxyethylamine → (2-Methoxy-ethyl)-(6-methyl-5-nitro-pyridin-2-yl)-amine

HRID 1811556노트

반응식

F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[N:3]=1.[CH3:12][O:13][CH2:14][CH2:15][NH2:16]>>[CH3:12][O:13][CH2:14][CH2:15][NH:16][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[N:3]=1

참가 물질

반응물 2

HCID 80182-Methoxyethylamine

HCID 124081856-Fluoro-2-methyl-3-nitropyridine

생성물 1

HCID 11241290(2-Methoxy-ethyl)-(6-methyl-5-nitro-pyridin-2-yl)-amine수율 107.9%

반응 조건

온도: 0 °C

실험 절차

A mixture of 2-fluoro-5-nitro-6-picoline (656 mg, 4.2 mmol) and 2-methoxyethylamine (365 μl, 4.2 mmol) was stirred at 0° C. After 10 min, crude (2-methoxy-ethyl)-(6-methyl-5-nitro-pyridin-2-yl)-amine (957 mg) was obtained as a solid. 1HNMR (CDCl3, 400 MHz) δ 2.77 (s, 3H), 2.85 (s, 2H), 3.40 (s, 3H), 3.57-3.60 (m, 2H), 5.51 (s br, 1H), 6.26-6.29 (m, 1H), 8.18-8.20 (m, 1H). Exact mass calculated for C9H13N3O3 211.10. found 212.2 (MH+).

출처 및 근거

ORD 기록: ord-b7f54275765a43d7b314ae08f04779a7
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08362248B2

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