HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1811556Generated: October 26, 2026
2-Methoxyethylamine → (2-Methoxy-ethyl)-(6-methyl-5-nitro-pyridin-2-yl)-amine
https://huagongshe.com/reaction/1811556
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 6-Fluoro-2-methyl-3-nitropyridine | HCID 12408185 | — |
| Product | (2-Methoxy-ethyl)-(6-methyl-5-nitro-pyridin-2-yl)-amine | HCID 11241290 | 107.9% |
Reaction Steps
A mixture of 2-fluoro-5-nitro-6-picoline (656 mg, 4.2 mmol) and 2-methoxyethylamine (365 μl, 4.2 mmol) was stirred at 0° C. After 10 min, crude (2-methoxy-ethyl)-(6-methyl-5-nitro-pyridin-2-yl)-amine (957 mg) was obtained as a solid. 1HNMR (CDCl3, 400 MHz) δ 2.77 (s, 3H), 2.85 (s, 2H), 3.40 (s, 3H), 3.57-3.60 (m, 2H), 5.51 (s br, 1H), 6.26-6.29 (m, 1H), 8.18-8.20 (m, 1H). Exact mass calculated for C9H13N3O3 211.10. found 212.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08362248B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-b7f54275765a43d7b314ae08f04779a7 |
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| Source note | uspto-grants-2013_01 |
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