反应详情

To a solution of ethyl 4-pyrazole carboxylate (3.57 mmol) in acetone (30 ml) was added potassium carbonate (35.7 mmol) and 1-bromo-3-phenylpropane (3.57 mmol). The suspension was refluxed overnight, after which the solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate and water, the organic layer dried over magnesium sulfate, filtered, and the filtrate evaporated under reduced pressure to give an oil, which was purified by preparative TLC, to give ethyl 1-(3-phenylpropyl)pyrazole-4-carboxylate.

1. temperatureThe suspension was refluxed overnight
2. customafter which the solvent was removed under reduced pressure
3. customThe residue was partitioned between ethyl acetate and water
4. dry with materialthe organic layer dried over magnesium sulfate
5. filtrationfiltered
6. customthe filtrate evaporated under reduced pressure
7. customto give an oil, which
8. customwas purified by preparative TLC