HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → N-(3-(2-Methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)-1H-indazol-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | N-(3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)-1H-indazol-4-amine | HCID 66612118 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(3-(2-Methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)-1H-indazol-4-amine | HCID 68516415 | — |
Reaction Steps
A mixture of N-(3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)-1H-indazol-4-amine (20 mg, 0.057 mmol) and 3-chloroperoxybenzoic acid (14.82 mg, 0.086 mmol, Aldrich, St. Louis, Mo.—77%) in dioxane (1 mL) was stirred at room temperature for 2 h. LCMS showed no starting material left. The reaction mixture was used for the next step of reaction without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362241B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-98f03ac6125546458dbe53f5b07de58b |
| Source note | uspto-grants-2013_01 |