m-Chloroperbenzoic acid → N-(3-(2-Methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)-1H-indazol-4-amine

HRID 1811907Notes

Reaction equation

HRID 1811907 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[C:9]([NH:14][C:15]3[C:16]4[CH:17]=[N:18][NH:19][C:20]=4[CH:21]=[CH:22][CH:23]=3)=[N:10][CH:11]=[CH:12][N:13]=2)[CH:5]=[C:4]([S:24][CH3:25])[N:3]=1.ClC1C=C(C=CC=1)C(OO)=[O:31]>O1CCOCC1>[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[C:9]([NH:14][C:15]3[C:16]4[CH:17]=[N:18][NH:19][C:20]=4[CH:21]=[CH:22][CH:23]=3)=[N:10][CH:11]=[CH:12][N:13]=2)[CH:5]=[C:4]([S:24]([CH3:25])=[O:31])[N:3]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 66612118N-(3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)-1H-indazol-4-amine

Product 1

HCID 68516415N-(3-(2-Methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)-1H-indazol-4-amine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of N-(3-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)-1H-indazol-4-amine (20 mg, 0.057 mmol) and 3-chloroperoxybenzoic acid (14.82 mg, 0.086 mmol, Aldrich, St. Louis, Mo.—77%) in dioxane (1 mL) was stirred at room temperature for 2 h. LCMS showed no starting material left. The reaction mixture was used for the next step of reaction without purification.

Workup

  1. waitleft
  2. customThe reaction mixture was used for the next step of reaction without purification

Sources & evidence

ORD record
ord-98f03ac6125546458dbe53f5b07de58b
Source dataset
uspto-grants-2013_01
Patent number
US08362241B2

Reaction notes

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