2,2,2-Trifluoroethanol → HCID 66600081, compound

HRID 1812110Notes

Reaction equation

HRID 1812110 reaction equation
[Br:1][C:2]1[C:3]([F:9])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[F:10][C:11]([F:15])([F:14])[CH2:12][OH:13]>>[Br:1][C:2]1[C:3]([F:9])=[N:4][C:5]([CH2:8][O:13][CH2:12][C:11]([F:15])([F:14])[F:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 404186163-Bromo-2-fluoro-6-methylpyridine

Product 1

HCID 66600081HCID 66600081, compound

Procedure

The title compound was prepared in an analogous manner to that described in Example 198 (Step 1) using 3-bromo-2-fluoro-6-methylpyridine (1.44 g, 7.58 mmol) (Waterstone Technology) and 2,2,2-trifluoroethanol. 1H NMR (400 MHz, d6-DMSO) δ 8.34 (1H, t, J=8.5 Hz); 7.34 (1H, d, J=7.9 Hz); 4.69 (2 H, s); 4.22 (2 H, q, J=9.5 Hz). m/z (ESI, +ve ion) 288/290 (M+H)+.

Sources & evidence

ORD record
ord-b8b2e192394840e5832592c7204b063b
Source dataset
uspto-grants-2013_01
Patent number
US08362241B2

Reaction notes

Loading…