5-(4-(Bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)nicotinaldehyde → HCID 49785596, compound

HRID 1812135Notes

Reaction equation

HRID 1812135 reaction equation
COC1C=CC(C[N:8](CC2C=CC(OC)=CC=2)[C:9]2[N:14]=[C:13]([CH3:15])[N:12]=[C:11]([C:16]3[C:17]([NH:24][C:25]4[CH:26]=[N:27][C:28]([O:31][CH3:32])=[CH:29][CH:30]=4)=[N:18][CH:19]=[C:20]([CH:23]=3)[CH:21]=O)[N:10]=2)=CC=1.C(O)(=O)C.[CH2:48]1[C:51]2([C:55](=[O:56])[NH:54][C:53](=[O:57])[NH:52]2)[CH2:50][NH:49]1>>[NH2:8][C:9]1[N:14]=[C:13]([CH3:15])[N:12]=[C:11]([C:16]2[CH:23]=[C:20]([CH2:21][N:49]3[CH2:48][C:51]4([C:55](=[O:56])[NH:54][C:53](=[O:57])[NH:52]4)[CH2:50]3)[CH:19]=[N:18][C:17]=2[NH:24][C:25]2[CH:26]=[N:27][C:28]([O:31][CH3:32])=[CH:29][CH:30]=2)[N:10]=1

Participants

3

Reactant 2

HCID 601552675-(4-(Bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)nicotinaldehydeHCID 66600719HCID 66600719, compound

Product 1

HCID 49785596HCID 49785596, compound

Procedure

The title compound was synthesized following an analogous procedure to Example 220 using 5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)nicotinaldehyde (109 mg, 0.189 mmol) and 2,5,7-triazaspiro[3.4]octane-6,8-dione acetate (56.9 mg, 0.283 mmol). 1H NMR (400 MHz, d6-DMSO) δ 11.75 (s, 1H); 10.71 (br. s., 1H); 8.72 (br. s., 1H); 8.60 (s, 1H); 8.54 (d, J=2.54 Hz, 1H); 8.20 (br. s., 1H); 8.16 (dd, J=9.00, 2.74 Hz, 1H); 7.90 (br. s., 1H); 7.75 (br. s., 1H); 6.82 (d, J=8.80 Hz, 1H); 3.84 (s, 3H); 2.44 (s, 3H). m/z (ESI, +ve ion) 463.1 (M+H)+.

Sources & evidence

ORD record
ord-239e698f46ee404588307845829b9a6a
Source dataset
uspto-grants-2013_01
Patent number
US08362241B2

Reaction notes

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