5-(4-(Bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)nicotinaldehyde → HCID 49785596, compound

Participants

Reaction Steps

The title compound was synthesized following an analogous procedure to Example 220 using 5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)nicotinaldehyde (109 mg, 0.189 mmol) and 2,5,7-triazaspiro[3.4]octane-6,8-dione acetate (56.9 mg, 0.283 mmol). 1H NMR (400 MHz, d6-DMSO) δ 11.75 (s, 1H); 10.71 (br. s., 1H); 8.72 (br. s., 1H); 8.60 (s, 1H); 8.54 (d, J=2.54 Hz, 1H); 8.20 (br. s., 1H); 8.16 (dd, J=9.00, 2.74 Hz, 1H); 7.90 (br. s., 1H); 7.75 (br. s., 1H); 6.82 (d, J=8.80 Hz, 1H); 3.84 (s, 3H); 2.44 (s, 3H). m/z (ESI, +ve ion) 463.1 (M+H)+.

Provenance & Evidence