反应详情

温度

0 °C

To a 50 mL round-bottomed flask was added 1,1′-carbonyldiimidazole (1.663 g, 10.25 mmol), (Fluka Chemie) DCM (25 mL). The solution was stirred at 0° C. using a water bath and treated in one portion with n-isopropylmethylamine (0.5 mL, 6.84 mmol) (Aldrich). The water bath was removed, and the solution was stirred at room temperature. After 2 hours all starting material was consumed. The reaction mixture was diluted with DCM (10 mL) and quenched with water. The organic layer was separated, dried over sodium sulfate and concentrated to afford N-isopropyl-N-methyl-1H-imidazole-1-carboxamide (0.920 g, 5.50 mmol, 80% yield).

1. customThe water bath was removed
2. stirringthe solution was stirred at room temperature
3. customAfter 2 hours all starting material was consumed
4. additionThe reaction mixture was diluted with DCM (10 mL)
5. customquenched with water
6. customThe organic layer was separated
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated