Dichloromethane → 4-(4-Bromo-benzenesulfonyloxy)-1-[2-tert-butoxycarbonylamino-2-(tetrahydro-pyran-4-yl)-acetyl]-pyrrolidine-2-carboxylic acid methyl ester

HRID 181358Notes

Reaction equation

HRID 181358 reaction equation
[C:21]([CH3:22])([CH3:23])([CH3:24])[O:25][C:26](=[O:27])[NH:28][CH:29]([C:30](=[O:31])[OH:32])[CH:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1.[CH3:1][O:2][C:3](=[O:4])[CH:5]1[NH:6][CH2:7][CH:8]([O:10][S:11](=[O:12])(=[O:13])[c:14]2[cH:15][cH:16][c:17]([Br:20])[cH:18][cH:19]2)[CH2:9]1.[CH:63]([N:64]([CH2:65][CH3:66])[CH:67]([CH3:68])[CH3:69])([CH3:70])[CH3:71].[Cl:72][CH2:73][Cl:74].[P-:39]([F:40])([F:41])([F:42])([F:43])([F:44])[F:45].[n:46]1([O:47][C:48]([N:49]([CH3:50])[CH3:51])=[N+:52]([CH3:53])[CH3:54])[c:55]2[n:56][cH:57][cH:58][cH:59][c:60]2[n:61][n:62]1>>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[N:6]([C:30]([CH:29]([NH:28][C:26]([O:25][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:27])[CH:33]2[CH2:34][CH2:35][O:36][CH2:37][CH2:38]2)=[O:31])[CH2:7][CH:8]([O:10][S:11](=[O:12])(=[O:13])[c:14]2[cH:15][cH:16][c:17]([Br:20])[cH:18][cH:19]2)[CH2:9]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 223091982-(((Tert-butoxy)carbonyl)amino)-2-(oxan-4-yl)acetic acidHCID 72357196Methyl 4-(4-bromophenyl)sulfonyloxypyrrolidine-2-carboxylate

Product 1

HCID 766050644-(4-Bromo-benzenesulfonyloxy)-1-[2-tert-butoxycarbonylamino-2-(tetrahydro-pyran-4-yl)-acetyl]-pyrrolidine-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-445dc0f6b89f4425bff1e9881805a849
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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