反应详情

温度

55 °C

To a one dram vial was added 20 mg (0.0604 mmol) of 3-(benzenesulfonyl)-2-methylsulfanyl-pyrido[1,2-a]pyrimidin-4-ylideneamine and 1.1 equivalents of ethanolamine in 750 ml of DMF. The vial was fitted with a TEFLON® lined cap and heated to 55° C. over night. The resulting product was then purified on a reverse phase preparative HPLC (XTerra™ MS C18 5.0 mM, MeOH/H2O as the eluent) to give 23 mg of the title compound as a brown solid; 10% yield.

1. customlined cap
2. customThe resulting product was then purified on a reverse phase preparative HPLC (XTerra™ MS C18 5.0 mM, MeOH/H2O as the eluent)