反应详情

温度

0 °C

3,5-Difluoro-4-(6-oxa-3-aza-bicyclo[3.1.0]hex-3-yl)-phenylamine (0.14 g, 0.66 mmol) was dissolved in dichloromethane (1.0 mL) and pyridine (0.11 mL, 1.32 mmol) and stirred at 0° C. Benzyl chloroformate (0.1 mL, 0.72 mmol) was added and the mixture was stirred at 0° C. for one hour. The reaction mixture was allowed to warm to room temperature, washed with water, brine and dried (MgSO4). The title compound was isolated by silica gel chromatography (0-1% MeOH-DCM) as a pale yellow solid.

1. temperatureto warm to room temperature
2. washwashed with water, brine
3. dry with materialdried (MgSO4)