Hydrochloric Acid → HCID 15486858, compound

HRID 1814052Notes

Reaction equation

HRID 1814052 reaction equation
C1(S([N:10]2[C:18]3[C:13](=[CH:14][C:15]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:16][CH:17]=3)[CH:12]=[C:11]2[C:23]2[S:24][CH:25]=[CH:26][N:27]=2)(=O)=O)C=CC=CC=1.[OH-].[K+].Cl>CO>[CH3:22][S:19]([C:15]1[CH:14]=[C:13]2[C:18](=[CH:17][CH:16]=1)[NH:10][C:11]([C:23]1[S:24][CH:25]=[CH:26][N:27]=1)=[CH:12]2)(=[O:21])=[O:20]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 22504364HCID 22504364, compound

Product 1

HCID 15486858HCID 15486858, compoundYield 104.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of the compound obtained in the step of Example 2 (4) (39 mg) in methanol (1 ml), a 1N aqueous potassium hydroxide solution (0.2 ml) was added at 15 to 30° C. and the mixture was stirred at 60° C. for 1 hour. To the reaction mixture was added 2N hydrochloric acid and the mixture was extracted with ethyl acetate. The organic layer was washed with water and dried. The solvent was distilled off under reduced pressure to obtain the desired product (27 mg).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. customdried
  4. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-3d13613ad0924b30b47200be3dd7e7ad
Source dataset
uspto-grants-2005_04
Patent number
US06875770B2

Reaction notes

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