{6-[4-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-chroman-2-yl}-acetic acid ethyl ester → {6-[4-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-chroman-2-yl}-acetic acid

HRID 1814156Notes

Reaction equation

HRID 1814156 reaction equation
FC(F)(F)C1C=CC(C2C=CC(CO)=CC=2)=NC=1.C([O:21][C:22](=[O:52])[CH2:23][CH:24]1[CH2:33][CH2:32][C:31]2[C:26](=[CH:27][CH:28]=[C:29]([S:34][CH2:35][C:36]3[CH:41]=[CH:40][C:39]([C:42]4[CH:47]=[CH:46][C:45]([C:48]([F:51])([F:50])[F:49])=[CH:44][N:43]=4)=[CH:38][CH:37]=3)[CH:30]=2)[O:25]1)C>>[F:51][C:48]([F:49])([F:50])[C:45]1[CH:46]=[CH:47][C:42]([C:39]2[CH:38]=[CH:37][C:36]([CH2:35][S:34][C:29]3[CH:30]=[C:31]4[C:26](=[CH:27][CH:28]=3)[O:25][CH:24]([CH2:23][C:22]([OH:52])=[O:21])[CH2:33][CH2:32]4)=[CH:41][CH:40]=2)=[N:43][CH:44]=1

Participants

3

Reactant 2

HCID 20770775{6-[4-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-chroman-2-yl}-acetic acid ethyl ester2×HCID 22280022{4-[5-(Trifluoromethyl)pyridin-2-yl]phenyl}methanol

Product 1

HCID 11155377{6-[4-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-chroman-2-yl}-acetic acid

Procedure

The title compound was prepared in the manner analogous to example 5E using 10D. MS m/z 272 (M+1). Step 6. Preparation of {6-[4-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-chroman-2-yl}-acetic acid ethyl ester (Compound 10F)

Sources & evidence

ORD record
ord-f1abd0279b4948c8810285abc56fa88f
Source dataset
uspto-grants-2005_04
Patent number
US06875780B2

Reaction notes

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