{5-[4-(Trifluoromethyl)phenyl]isoxazol-3-yl}methan-1-ol → {6-[5-(4-Trifluoromethyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-chroman-2-yl}-acetic acid

HRID 1814158Notes

Reaction equation

HRID 1814158 reaction equation
FC(F)(F)C1C=CC(C2ON=C(CO)C=2)=CC=1.C([O:20][C:21](=[O:50])[CH2:22][CH:23]1[CH2:32][CH2:31][C:30]2[C:25](=[CH:26][CH:27]=[C:28]([S:33][CH2:34][C:35]3[CH:39]=[C:38]([C:40]4[CH:45]=[CH:44][C:43]([C:46]([F:49])([F:48])[F:47])=[CH:42][CH:41]=4)[O:37][N:36]=3)[CH:29]=2)[O:24]1)C>>[F:48][C:46]([F:47])([F:49])[C:43]1[CH:44]=[CH:45][C:40]([C:38]2[O:37][N:36]=[C:35]([CH2:34][S:33][C:28]3[CH:29]=[C:30]4[C:25](=[CH:26][CH:27]=3)[O:24][CH:23]([CH2:22][C:21]([OH:50])=[O:20])[CH2:32][CH2:31]4)[CH:39]=2)=[CH:41][CH:42]=1

Participants

3

Reactant 2

HCID 22064161{5-[4-(Trifluoromethyl)phenyl]isoxazol-3-yl}methan-1-olHCID 69514714{6-[5-(4-Trifluoromethyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-chroman-2-yl}-acetic acid ethyl ester2×

Product 1

HCID 11396735{6-[5-(4-Trifluoromethyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-chroman-2-yl}-acetic acid

Procedure

The title compound was prepared in a manner analogous to Example 5E using 13B. MS m/z 262 (M+1). Step 4. Preparation of {6-[5-(4-Trifluoromethyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-chroman-2-yl}-acetic acid ethyl ester (Compound 13D)

Sources & evidence

ORD record
ord-ebadb0914d2b487f814d10cc48f62f63
Source dataset
uspto-grants-2005_04
Patent number
US06875780B2

Reaction notes

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