HCID 20770804, compound → HCID 20770800, compound

HRID 1814177Notes

Reaction equation

HRID 1814177 reaction equation
COC(=O)C(C1C=CC(SCC2C=CC(C3C=CC(C(F)(F)F)=CN=3)=CC=2)=C(OC)C=1)(C)C.[CH3:34][O:35][C:36](=[O:49])[CH2:37][N:38]1[C:42]2[CH:43]=[CH:44][C:45]([SH:47])=[CH:46][C:41]=2[O:40][C:39]1=[O:48].[F:50][C:51]([F:69])([F:68])[C:52]1[CH:67]=[CH:66][C:55]([CH2:56][O:57][C:58]2[CH:63]=[CH:62][CH:61]=[C:60]([CH2:64]Cl)[CH:59]=2)=[CH:54][CH:53]=1>>[CH3:34][O:35][C:36](=[O:49])[CH2:37][N:38]1[C:42]2[CH:43]=[CH:44][C:45]([S:47][CH2:64][C:60]3[CH:61]=[CH:62][CH:63]=[C:58]([O:57][CH2:56][C:55]4[CH:66]=[CH:67][C:52]([C:51]([F:50])([F:68])[F:69])=[CH:53][CH:54]=4)[CH:59]=3)=[CH:46][C:41]=2[O:40][C:39]1=[O:48]

Participants

4

Reactant 3

HCID 20770804HCID 20770804, compoundHCID 20770807HCID 20770807, compoundHCID 22280116HCID 22280116, compound

Product 1

HCID 20770800HCID 20770800, compoundYield 25%

Procedure

Compound 76D was prepared analogously to compound 21D using the product prepared from compound 76C and 6B. Yield was 25% after flash column purification. MS m/z 504 (M+1). 400 MHz 1H NMR (DMSO-d6) δ 7.61-6.71 (m, 11H), 5.05 (s, 2H), 4.50 (s, 2H), 3.99 (s, 2H), 3.74 (s, 3H).

Workup

  1. customYield was 25% after flash column purification

Sources & evidence

ORD record
ord-6d5674adbd55413d89697c875c7a41f8
Source dataset
uspto-grants-2005_04
Patent number
US06875780B2

Reaction notes

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