3-(Chloromethyl)-5-(4-chlorophenyl)-1,2-oxazole → 2-(6-((5-(4-Chlorophenyl)isoxazol-3-yl)methoxy)-5-methylbenzo[b]thiophen-3-yl)acetic acid

HRID 1814182Notes

Reaction equation

HRID 1814182 reaction equation
Cl[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[O:5][N:4]=1.C[O:16][C:17](=[O:30])[CH2:18][C:19]1[C:20]2[CH:27]=[C:26]([CH3:28])[C:25]([OH:29])=[CH:24][C:21]=2[S:22][CH:23]=1.COC(=O)CC1C2C=CC=C(OCC3C=C(C4C=CC(Cl)=CC=4)ON=3)C=2SC=1>>[CH3:28][C:26]1[C:25]([O:29][CH2:2][C:3]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=3)[O:5][N:4]=2)=[CH:24][C:21]2[S:22][CH:23]=[C:19]([CH2:18][C:17]([OH:30])=[O:16])[C:20]=2[CH:27]=1

Participants

4

Reactant 3

HCID 14811003-(Chloromethyl)-5-(4-chlorophenyl)-1,2-oxazoleHCID 20770860(6-Hydroxy-5-methyl-benzo[b]thiophen-3-yl)-acetic acid methyl esterHCID 20770869{7-[5-(4-Chloro-phenyl)-isoxazol-3-ylmethoxy]-benzo[b]thiophen-3-yl}-acetic acid methyl ester

Product 1

HCID 225048432-(6-((5-(4-Chlorophenyl)isoxazol-3-yl)methoxy)-5-methylbenzo[b]thiophen-3-yl)acetic acid

Procedure

The title compound was prepared from commercially available 3-chloromethyl-5-(4-chloro-phenyl)-isoxazole and compound 78C in a manner analogous to compound 77C.

Sources & evidence

ORD record
ord-8e312637b6d64f34b57a4821104b26f9
Source dataset
uspto-grants-2005_04
Patent number
US06875780B2

Reaction notes

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