Serinol → 2-[[(3-Chloro-2-fluorophenyl)methyl]thio]-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-7(8H)-pteridinone

HRID 1814247Notes

Reaction equation

HRID 1814247 reaction equation
Br[C:2]1[C:11]2[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=2[N:5]=[C:4]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:16]=2[F:22])[N:3]=1.[NH2:23][CH:24]([CH2:27][OH:28])[CH2:25][OH:26]>>[Cl:21][C:17]1[C:16]([F:22])=[C:15]([CH2:14][S:13][C:4]2[N:3]=[C:2]([NH:23][CH:24]([CH2:27][OH:28])[CH2:25][OH:26])[C:11]3[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=3[N:5]=2)[CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 68294SerinolHCID 225059834-Bromo-2-[[(3-chloro-2-fluorophenyl)methyl]thio]-7(8H)-pteridinone

Product 1

HCID 225059422-[[(3-Chloro-2-fluorophenyl)methyl]thio]-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-7(8H)-pteridinoneYield 66.3%

Procedure

The titled compound (51 mg) was prepared by the method of Example 6, step (f) using the product from Example 6, step (e) (75 mg) and 2-amino-1,3-propanediol (37 mg).

Sources & evidence

ORD record
ord-313557b7d540455abf68f3582d8b2d38
Source dataset
uspto-grants-2005_04
Patent number
US06875868B2

Reaction notes

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