(3-Methylphenyl)methanethiol → 4-[[(1R)-2-Hydroxy-1-methylethyl]amino]-2-[[(3-methylphenyl)methyl]thio]-7(8H)-pteridinone

HRID 1814255Notes

Reaction equation

HRID 1814255 reaction equation
F[C:2]1[C:7](F)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10]([C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1)(=O)=O.[CH3:29]C1C=C(CS)C=CC=1>>[OH:26][CH2:25][C@H:24]([NH:23][C:21]1[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=[C:13]([S:10][CH2:9][C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([CH3:29])[CH:2]=2)[N:22]=1)[CH3:27]

Participants

3

Reactant 2

HCID 2801207(3-Methylphenyl)methanethiolHCID 688171932-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

Product 1

HCID 688141424-[[(1R)-2-Hydroxy-1-methylethyl]amino]-2-[[(3-methylphenyl)methyl]thio]-7(8H)-pteridinoneYield 43.2%

Procedure

The titled compound (75 mg) was prepared by the method of Example 13, step (c) using the product from Example 13, step (a) (0.20 g) and 3-methyl-benzenemethanethiol (75 mg).

Sources & evidence

ORD record
ord-6c5ce1bad0044461bdbe19dd603570a1
Source dataset
uspto-grants-2005_04
Patent number
US06875868B2

Reaction notes

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