HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-[2-(2-Isoquinolin-4-yl-ethoxy)-benzenesulfonylamino]-4-oxo-butyric acid trifluoro-acetate salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Reactant | (S)-3-[2-(2-isoquinolin-4-yl-ethoxy)-benzenesulfonylamino]-4-oxo-butyric acid tert-butyl ester | HCID 86588201 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-[2-(2-Isoquinolin-4-yl-ethoxy)-benzenesulfonylamino]-4-oxo-butyric acid trifluoro-acetate salt | HCID 86588202 | — |
Reaction Steps
To (S)-3-[2-(2-isoquinolin-4-yl-ethoxy)-benzenesulfonylamino]-4-oxo-butyric acid tert-butyl ester was added 3:1 dichloromethane/trifluoroacetic acid (20 mL) and water (200 μL). After 2 h at room temperature, toluene (20 ml) was added and the solvent was removed under reduced pressure to give 3-[2-(2-isoquinolin-4-yl-ethoxy)-benzenesulfonylamino]-4-oxo-butyric acid trifluoro-acetate salt as a colorless foam (36 mg). MS (APCI) m/z 429.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06875765B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-780a1bdb61ef4756ac28c63936a9cffc |
| Source note | uspto-grants-2005_04 |