HRID1814345

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)C[C@H](NS(=O)(=O)c1ccc([N+](=O)[O-])cc1OCc1ccccc1)C(N)=O

HCID69692796

(S)-3-(2-Benzyloxy-4-nitro-benzenesulfonylamino)-succinamic acid tert-butyl ester

C21H25N3O8S

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)C[C@H](NS(=O)(=O)c1ccc(N)cc1OCc1ccccc1)C(N)=O

HCID69692844

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID935

Nickel

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A solution of (S)-3-(2-benzyloxy-4-nitro-benzenesulfonylamino)-succinamic acid tert-butyl ester (1.30 g, 2.70 mmol) in THF (75 mL) was shaken with Raney Nickel (0.50 g) under H2 (33 psi) for 18 h using a Parr apparatus. The reaction mixture was filtered through celite and concentrated. (S)-3-(4-Amino-2-benzyloxy-benzenesulfonylamino)-succinamic acid tert-butyl ester was obtained (1.20 g, 98%) as an off white solid. MS (APCI) m/z 448.1 (M−1).

WORKUP

后处理

filtrationThe reaction mixture was filtered through celite and
concentrationconcentrated