反应详情

A mixture of 0.5 g (4.23 mmol) indazole, 0.3 mL (S)-propylene oxide (4.4 mmol), 0.53 g potassium t-butoxide (4.3 mmol) and 15 mL of 25:1 t-BuOH:THF was stirred in a sealed tube at 70° C. overnite. The solvent was removed in vacuo, 50 mL ethyl acetate was added to the residue, the mixture was filtered, concentrated and the residue purified by chromatography over silica eluting with 1:1 EtOAc:hexanes to yield 0.250 g (1.42 mmol, 67%) of the title compound as a viscous oil. MS (APCI) m/z 177 (M+1).

1. customThe solvent was removed in vacuo, 50 mL ethyl acetate
2. additionwas added to the residue
3. filtrationthe mixture was filtered
4. concentrationconcentrated
5. customthe residue purified by chromatography over silica eluting with 1:1 EtOAc