Urea → 1,3(2H,4H)-isoquinolinedione

HRID 1814447Notes

Reaction equation

HRID 1814447 reaction equation
[C:1]1(=O)[O:7][C:5](=[O:6])[C:4]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:3]2[CH2:2]1.[NH2:13]C(N)=O>O>[C:1]1(=[O:7])[NH:13][C:5](=[O:6])[C:4]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:3]2[CH2:2]1

Participants

4

Reactant 2

HCID 1176UreaHCID 12801Homophthalic anhydride

Product 1

HCID 3494351,3(2H,4H)-isoquinolinedioneYield 52.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Homophthalic anhydride (20 g) and urea (60 g) were reacted at 170° C. for 1 hr. The reaction mixture was cooled, water (500 ml) was added thereto, and then the resulting precipitates were collected by filtration. The precipitate were washed with water and dried in hot air, to give 10.5 g of homophthalimide as a white powder. (17-2) 1,3-Dichloroisoquinoline

Workup

  1. temperatureThe reaction mixture was cooled
  2. customthe resulting precipitates
  3. filtrationwere collected by filtration
  4. washThe precipitate were washed with water
  5. customdried in hot air

Sources & evidence

ORD record
ord-ca7a91a015d1422eab07d46fa1a2f7c7
Source dataset
uspto-grants-2005_04
Patent number
US06875761B2

Reaction notes

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