HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 3-[4-(4-Morpholinyl)phenyl]isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | N-methyl-2-toluamide | HCID 75111 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-[4-(4-Morpholinyl)phenyl]isoquinolin-1-one | HCID 22503318 | 41.5% |
Reaction Steps
4-(4-Morpholinyl)benzonitrile obtained by reacting 4-fluorobenzonitrile (10.89 g) and morpholine (7.84 g) in the presence of potassium carbonate (12.42 g) in dimethyl sulfoxide (45 ml) was reacted with N-methyl-o-toluamide (8.019 g) according to Example 10-1, to give 6.840 g of 3-[4-(4-morpholinyl)phenyl]isoquinolin-1-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06875761B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-5dfc749ee241424eb01a89341e9fdc18 |
| Source note | uspto-grants-2005_04 |