Phosphorus oxychloride → HCID 22503052, compound

HRID 1814477Notes

Reaction equation

HRID 1814477 reaction equation
[CH3:1][NH:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:5]=1[CH3:12].[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19](C#N)=[CH:18][CH:17]=1.P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:3]1[C:4]2[C:5](=[CH:6][C:7]([O:10][CH3:11])=[CH:8][CH:9]=2)[CH:12]=[C:1]([C:19]2[CH:22]=[CH:23][C:16]([O:15][CH3:14])=[CH:17][CH:18]=2)[N:2]=1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 701294-MethoxybenzonitrileHCID 22502967HCID 22502967, compound

Product 1

HCID 22503052HCID 22503052, compound

Procedure

6-Methoxy-3-(4-methoxyphenyl)isoquinolin-1-one (0.40 g) obtained by reacting N-methyl-4-methoxy-2-methylbenzamide (1.0 g) and 4-methoxybenzonitrile (0.75 g) according to Example 10-1 was reacted with phosphorus oxychloride (10 ml) according to Example 10-2, to give 1-chloro-6-methoxy-3-(4-methoxyphenyl)isoquinoline.

Sources & evidence

ORD record
ord-8ae987fd488246a4b91306c177d1240d
Source dataset
uspto-grants-2005_04
Patent number
US06875761B2

Reaction notes

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