反应详情

4-(4-Ethylpiperazin-1-yl)-6-[4-(2-t-butyldiphenylsilyloxypropoxy)phenyl]thieno[3,2-c]pyridine of 3.38 g (5.31 mmol) was dissolved in THF of 20 ml and stirred at room temperature. To the mixture was added 1.0M tetrabutylammonium fluoride/THF solution of 10.6 ml (2.0 equivalents), and the mixture was stirred for 8 hr. The solvent was evaporated, and to the resulting residue was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed sequentially with water (three times) and brine, and dried over magnesium sulfate. The solvent was evaporated, and the resulting residue was purified by NH-silica gel column chromatography (n-hexane/ethyl acetate system), to give the title compound as a colorless oil (1.65 g, yield; 78%).

1. stirringthe mixture was stirred for 8 hr
2. customThe solvent was evaporated
3. additionto the resulting residue was added water
4. extractionthe mixture was extracted with ethyl acetate
5. washThe organic layer was washed sequentially with water (three times) and brine
6. dry with materialdried over magnesium sulfate
7. customThe solvent was evaporated
8. customthe resulting residue was purified by NH-silica gel column chromatography (n-hexane/ethyl acetate system)