Hydrochloric Acid → HCID 22501945, compound

HRID 1814675Notes

Reaction equation

HRID 1814675 reaction equation
C([O:3][C:4]([C:6]1[CH:45]=[CH:44][C:9]2[N:10]=[C:11]([NH:13][C:14]([N:16]([C:32]3[CH:37]=[CH:36][C:35]([CH:38]4[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]4)=[CH:34][CH:33]=3)[CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24](=[O:31])[NH:25][C:26]4[N:27]=[N:28][NH:29][N:30]=4)=[CH:20][CH:19]=3)=[O:15])[S:12][C:8]=2[CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[CH:38]1([C:35]2[CH:34]=[CH:33][C:32]([N:16]([CH2:17][C:18]3[CH:19]=[CH:20][C:21]([C:24](=[O:31])[NH:25][C:26]4[N:27]=[N:28][NH:29][N:30]=4)=[CH:22][CH:23]=3)[C:14](=[O:15])[NH:13][C:11]3[S:12][C:8]4[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:45]=[CH:44][C:9]=4[N:10]=3)=[CH:37][CH:36]=2)[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23550117HCID 23550117, compound

Product 1

HCID 22501945HCID 22501945, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-{3-(4-Cyclohexylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzothiazole-6-carboxylic acid ethyl ester (16 mg, 0.025 mmol) was dissolved in ethanol (4 mL). Sodium hydroxide (1 mL, 4 N) was added and the reaction mixture was left at room temperature for 16 hours. Hydrochloric acid (4 mL, 1 N) was added, and the resulting precipitate was subsequently collected by filtration to afford the title compound.

Workup

  1. filtrationthe resulting precipitate was subsequently collected by filtration

Sources & evidence

ORD record
ord-664f831f3ec84ee48817c3bcacda10ce
Source dataset
uspto-grants-2005_04
Patent number
US06875760B2

Reaction notes

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