HRID1814695

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1049

Pyridine

C5H5N

HCID4327891

Pentafluorophenyl trifluoroacetate

C8F8O2

结构：CC(C)(C)c1ccc(N(Cc2ccc(C(=O)Nc3nn[nH]n3)cc2)C(=O)Nc2cccc(C(=O)O)c2)cc1

HCID22501965

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)c1ccc(N(Cc2ccc(C(=O)Nc3nn[nH]n3)cc2)C(=O)Nc2cccc(C(=O)Oc3c(F)c(F)c(F)c(F)c3F)c2)cc1

HCID18346946

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 25 °C

PROCEDURE

实验过程

To the above resin bound 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid was added a solution of pyridine (500 μL) in DMF (5 mL) followed by pentafluorophenyl trifluoroacetate (850 μL). The mixture was shaken for 4 hours at 25° C., filtered and washed with DMF (2×10 mL), affording the resin bound title compound.

WORKUP

后处理

filtrationfiltered
washwashed with DMF (2×10 mL)
customaffording the resin

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-037a32ba1b414c8898caadacac476373
来源数据集: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06875760B2
来源说明: uspto-grants-2005_04

反应 SMILES

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31](=[O:38])[NH:32][C:33]3[N:34]=[N:35][NH:36][N:37]=3)=[CH:27][CH:26]=2)[C:12](=[O:23])[NH:13][C:14]2[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=2)[C:17]([OH:19])=[O:18])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].N1C=CC=CC=1.FC(F)(F)C(O[C:50]1[C:55]([F:56])=[C:54]([F:57])[C:53]([F:58])=[C:52]([F:59])[C:51]=1[F:60])=O>CN(C=O)C>[F:56][C:55]1[C:50]([O:18][C:17](=[O:19])[C:16]2[CH:20]=[CH:21][CH:22]=[C:14]([NH:13][C:12]([N:11]([C:8]3[CH:7]=[CH:6][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][CH:9]=3)[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([C:31](=[O:38])[NH:32][C:33]4[N:34]=[N:35][NH:36][N:37]=4)=[CH:27][CH:26]=3)=[O:23])[CH:15]=2)=[C:51]([F:60])[C:52]([F:59])=[C:53]([F:58])[C:54]=1[F:57]