反应详情

Cyanamide (5.04 g, 120 mmol) was dissolved in 40 mL of 40% sodium hydroxide. To this solution at 0° C., phenylacetyl chloride (3.97 mL, 30 mmol) in 30 mL of acetone was added over 1 h. After stirring at room temperature for 2 h, the reaction mixture as acidified with concentrated HCl to pH 2. Acetone was removed in vacuo. The resulting suspension was extracted with methylene chloride (30 mL×4). The combined organic extracts were washed with brine and dried over magnesium sulfate. Solvent was removed in vacuo to give N-cyano-2-phenylacetamide (3.96 g, 82%) as a yellow oil.

1. customAcetone was removed in vacuo
2. extractionThe resulting suspension was extracted with methylene chloride (30 mL×4)
3. washThe combined organic extracts were washed with brine
4. dry with materialdried over magnesium sulfate
5. customSolvent was removed in vacuo